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KMID : 1007020080060020103
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Korean Soceity of Osteroporosis
2008 Volume.6 No. 2 p.103 ~ p.111
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The Effect of Black Cohosh Root Extract on the Vasomotor Symptom and Bone of Postmonopausal Women
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Oh Young-Rim
Kim Heung-Yeol
Kim Hong-Bae
Eo Wan-Kyu
Jung Hyuk
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Abstract
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Objectives: To evaluate the effect of black cohosh root extract (BCRE) on vasomotor symptoms and bone mineral density in postmenopausal women.
Methods: This prospective randomized clinical trial examined the effects of BCRE on vasomotor symptom, bone mineral density, and biochemical markers of bone turnover in 90 postmenopausal women. Treatment included BCRE (group I, n=30) or 0.625 mg CEE (group II, n=30), control group (group III, n=30) for 6 months. Kupperman index, BMD and biochemical bone marker were measured at 0, 3 and 6 months.
Results: Kupperman index decreased significantly at 3 months and 6 months of the treatment in group I and group II (P<0.05). BMD of lumbar spine increased significantly during the treatment in group I and group II (P<0.05). Urinary deoxypyridinolin decreased significantly at 3 months and 6 months of the treatment in group I and group II (P<0.05).
Conclusion: BCRE appears to be a safe and effective alternate to hormone therapy for vasomotor symptom and may be especially useful in women with intolerance or contraindication to traditional hormone therapy.
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KEYWORD
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BCRE (black cohosh root extract), Kupperman index, BMD, Biochemical bone marker
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